John Bacher Selected Research

Isoleucine-tRNA Ligase

5/2005	Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.
10/2004	Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.

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John Bacher Research Topics

Disease

12	Invasive Pulmonary Aspergillosis 01/2021 - 01/2002
8	Body Weight (Weight, Body) 06/2009 - 01/2002
6	Pulmonary Aspergillosis 06/2009 - 01/2002
5	Candidiasis (Moniliasis) 11/2008 - 06/2002
4	Pulmonary Infarction 11/2010 - 01/2002
4	Aspergillosis 10/2006 - 01/2002
3	Lung Injury 06/2009 - 01/2002
2	Meningoencephalitis 11/2008 - 01/2008
2	Infections 10/2004 - 07/2003
1	Brain Neoplasms (Brain Tumor) 04/2010
1	Infarction (Infarctions) 06/2009
1	Zygomycosis (Phycomycosis) 11/2008
1	Invasive Candidiasis 01/2006
1	Burns 11/2005
1	Wounds and Injuries (Trauma) 11/2005
1	Primary Immunodeficiency Diseases 10/2005
1	Bacterial Infections (Bacterial Infection) 10/2005
1	Central Nervous System Infections (Central Nervous System Infection) 05/2005
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2004
1	Persistent Infection 07/2003

Drug/Important Bio-Agent (IBA)

10	Amphotericin B (Amphotericin)FDA LinkGeneric 10/2006 - 01/2002
8	galactomannanIBA 01/2021 - 01/2002
4	Biomarkers (Surrogate Marker)IBA 11/2010 - 04/2006
3	EchinocandinsIBA 01/2008 - 01/2002
3	Micafungin (FK463)FDA Link 01/2008 - 06/2002
3	liposomal amphotericin B FDA Link 10/2006 - 06/2002
3	ER 30346 (ravuconazole)IBA 10/2006 - 06/2003
3	Deoxycholic Acid (Sodium Deoxycholate)IBA 04/2006 - 01/2002
2	deoxycholate drug combination amphotericin BIBA 11/2010 - 10/2006
2	polyglucosanIBA 11/2010 - 11/2008
2	Dihydrotachysterol (AT 10)IBA 06/2009 - 05/2005
2	TriazolesIBA 10/2006 - 06/2003
2	EnzymesIBA 07/2006 - 10/2004
2	Isoleucine-tRNA LigaseIBA 05/2005 - 10/2004
2	2- amino- 4- methylenecyclopentane- 1- carboxylic acidIBA 05/2005 - 10/2004
2	Fluconazole (Zonal)FDA LinkGeneric 05/2005 - 10/2004
2	AntigensIBA 10/2004 - 01/2002
1	posaconazole FDA Link 01/2021
1	Cisplatin (Platino)FDA LinkGeneric 04/2010
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 04/2010
1	Carboplatin (JM8)FDA LinkGeneric 04/2010
1	Voriconazole (Vfend)FDA LinkGeneric 06/2009
1	Anidulafungin FDA Link 06/2009
1	28S Ribosomal RNAIBA 11/2008
1	beta-GlucansIBA 11/2008
1	Biological ProductsIBA 04/2006
1	Fungal DNAIBA 01/2006
1	DNA (Deoxyribonucleic Acid)IBA 01/2006
1	IntegrinsIBA 10/2005
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2004
1	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 10/2004
1	ImmunosorbentsIBA 10/2004
1	Lysine (L-Lysine)FDA Link 04/2004
1	C-PeptideIBA 01/2004
1	Streptozocin (Streptozotocin)FDA Link 01/2004
1	OMPIIBA 01/2002
1	Caspofungin (Cancidas)FDA Link 01/2002
1	Pharmaceutical PreparationsIBA 01/2002

Therapy/Procedure

9	Therapeutics 11/2010 - 01/2002
1	Drug Therapy (Chemotherapy) 02/2007
1	Vascularized Composite Allotransplantation 11/2005
1	Injections 10/2004